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Opicapone is prescribed alongside other medications, such as levodopa/carbidopa, for the treatment of Parkinson's disease. It is part of a group of drugs called COMT inhibitors. Patients taking levodopa often experience a reduction in its effectiveness between doses, leading to a return or worsening of symptoms. Opicapone works by inhibiting the enzyme COMT, which breaks down levodopa in the body, allowing levodopa to be more effective and last longer.